孕妇未足月胎膜早破合并绒毛膜羊膜炎的监测

DETECTION OF CHORIOAMNIONITIS IN PATIENTS WITH PRETERM PREMATURE RUPTURE OF MEMBRANES

目的探讨未足月胎膜早破(PPROM)孕妇血C-反应蛋白(CRP)及白细胞介素-6(IL-6)监测绒毛膜羊膜炎(CMA)的意义。方法于PPROM孕妇(PPROM组)及正常孕妇(对照组)终止妊娠时采集静脉血测定CRP及IL-6含量,并收集胎盘进行病理学检查。结果①PPROM组组织CMA发病率为100%(37/37),对照组为6%(3/50),差异有统计学意义(P<0.05)。②PPROM组CMAⅠ级者与对照组比较,母血CRP及IL-6含量均明显升高(P均<0.05);而与组内CMAⅡ、Ⅲ级者比较,二指标含量明显下降(P均<0.05)。③PPROM组母血CRP及IL-6水平与组织CMA分级呈正相关,r分别为0.75和0.79(P均<0.05)。结论PPROM组组织CMA可导致母血CRP及IL-6升高,且二指标水平与CMA程度呈正相关。

Objective To study the relationship between C- reactive protein（CRP） of maternal serum, interleukin-6（IL- 6） and chorioamnionitis （CMA） in patients with preterm premature rupture of the membranes（PPROM）. Methods Maternal blood was collected for determination of CRP and IL - 6, and plancents were checked pathologically when women with PPROM（PPROM group） and normal pregnant woman（control group） ended their pregnancy. Results ①The incidence of CMA in PPROM group was 100%, but maternal serum CRP and IL- 6 determination raised significantly in the detection of positive AF pathogen（P〈0.05）. ②Maternal serum CRP 0.15g/L and IL - 6 6.12 × 10^-8g/L can be used to diagnosed early CMA. Conclusion The maternal serum CRP and IL-6 determination can be used as the prediction of early CMA conveniently.