出血坏死型胰腺炎患者血浆中D-二聚体测定的临床价值

Clinical Value of Plasma D-dimer in Patients with Severe Acute Pancreatitis

目的:探讨出血坏死型胰腺炎患者血浆中D-二聚体浓度的临床价值。方法:对30例出血坏死型胰腺炎患者采用双抗体夹心ELISA法测定血浆D-二聚体浓度,并与同期42例水肿型急性胰腺炎患者作比较。结果:出血坏死型胰腺炎患者血浆中D-二聚体浓度水平显著高于水肿型急性胰腺炎患者(P<0.05)。结论:血浆D-二聚体含量变化与出血坏死型胰腺炎的病程演变关系密切;早期检测血浆D-二聚体浓度水平对出血坏死型胰腺炎病情的判断与预后具有一定的临床参考价值。

Objective： To explore the clinical value of the concentration of plasma D-dimer in patients with severe acute pancreatitis. Methods： Contents of plasma D - dimer were determined by double antibody sandwich（ELISA） and compared with other 42 cases of mild acute pancreatitis. Results： Compared with mild acute pancreatitis, the plasma D- dimer level were increased in severe pancreatitis（P 〈 0.05）. Conclusion： The change of plasma D-dimer level are closely related to the clinical development in patients with severe acute pancreatitis. Early detection of D-dimer in severe acute pancreatitis has some effect to estimate state and prognosis.