乳腺癌c-erbB-2原癌基因与ER、PR的关系和临床意义

Correlation between expression of C-erbB-2 protooncogene and ER、PR in primary breast carcinoma and its clinical significance

目的探讨乳腺癌组织中c-erbB-2原癌基因和ER、PR表达关系及其临床意义。方法采用免疫组织化学方法对我院95例乳腺癌组织进行c-erbB-2和ER、PR测定,分析它们之间的表达关系及其临床意义。结果c-erbB-2阳性表达者占69.47%。c-erbB-2阳性率在ER阳性组为48.39%,在ER阴性组为79.69%(P<0.005);c-erbB-2阳性率在PR阳性组为48.15%,在PR阴性组为77.94%(P<0.01)。,随诊2年以上,激素受体阳性复发率约为4%,阴性者约为13%,c-erbB-2阳性复发率为14.0%,阴性者为2.5%(P<0.05)。结论c-erbB-2阳性表达与ER、PR阳性表达呈负相关,c-erbB-2是判断乳腺癌预后的有效指标,联合检测C-erbB-2、ER、PR可指导临床综合治疗。

Objective To explore the correlation between expression of c-erbB-2 protooncogene and receptors of estrogen and progestogen in primary breast carcinoma and its clinical significance. Methods We used immunohistochemical methods to detect the expression of c-erbB-2,ER,PR in 95 cases of primary breast carcinoma to analyze the correlation between them and its clinical significance. Results The positive expression of c- erbB-2 was 69.47%. The positive rate of expression of c-erbB-2 was 48.39% in the group with positive expression of ER, 79.69% in the group with negative expression of ER （P〈0.05）;The positive rate of expression of c-erbB-2 was 48.15% in the group with positive expression of PR, 77.94% in the group with negative expression of PR （P〈0.01）. After 2 years following up, the recurrence rates of ER/PR（＋） ,and ER/PR（-） were 4% and 13% respectively. The recurrence rates in c-erbB-2 （＋） and c-erbB-2 （-） were 14.0% and 2 .5% respectively （P〈0.05）. Conclusions The positive expression of c-erbB-2 had a reverse correlation with ER,PR, c- erbB-2 is an useful prognostic factor in patients with breast carcinoma,the combined detection of c-erbB-2, ER,PR has important significance for clinical therapy.