美能治疗抗结核药物所致的肝损害临床分析

Clinical analysis of minophagenC (SNMC) in the treatment of anti-tuberculosis drug-induced liver function lesion

目的观察美能治疗抗结核药药物性肝损害的疗效。方法260例抗结核药所致的中重度药物性肝损害病人随机分为两组,治疗组采用美能,对照组采用阿拓莫兰与苦黄联合。结果两组治疗效果均较好,TBil、ALT、ESR治疗后的恢复情况为:治疗组总有效率95.4%、96.9%、90.8%,对照组总有效率92.3%、93.8%、88.5%。但治疗组肝功能的恢复速度明显快于对照组,两组中有效治疗者TBil、ALT、ESR恢复的平均时间分别为:治疗组(16.3±0.3)、(12.1±0.2)、(17.5±0.3)天,对照组(27.9±0.6)、(23.3±0.3)、(27.4±0.4)天。结论美能治疗中重度抗结核药药物性肝损害效果良好,能更有效防止因发生肝损害而中断治疗。

Objective To study the efficacy of strong Neo-MinophagenC （SNMC） in treating antl-tuberculosis drug-lnduced liver function lesion. Methods 260 patients suffering with liver function lesion were divided into two groups randomly： treatment and control groups. The treatment group was given SNMC and the control group was given Glutathione sequenced with KU-HUANG. Results The recovery conditions of the treatment and control group were as seen below ： The response rates of TBiL, ALT and ESR were 95.4%, 96. 9% and 90. 8% in the treatment group respectively, and the respective rates in the control group were 92. 3%, 93.8% and 88.5% respectively. Time period of recovering were respectively 16.3 ± 0.3, 12. 1 ± 0. 2, 17.5 ± 0.3 （days） in the treatment group, and 27.9 ± 0. 6, 23.3 ± 0. 3, 27.4 ± 0.4 （days） in the control group. There was similar efficacy rate between the two groups, but time for which the markers recovered to normality or near normality was shorter in the treatment group than that in the control group. Conclusion The use of SNMC in treating the liver function lesion has a shorter recovery time period than Glutathione sequenced with KU-HUANG.