原发性肝细胞癌828例临床实验室特征分析

Analysis of clinical laboratory parameters of 828 patients with hepatocellular carcinoma

目的:回顾性分析原发性肝细胞癌(HCC)临床常用实验室指标,寻找与HCC诊断相关的指标。方法:收集828例病理确诊为HCC患者术前检查中的常用肿瘤标志物、血清学生化指标、乙型肝炎病毒(HBV)标志物、HBV DNA滴度等临床实验室数据,分析其与肿瘤大小和肿瘤病理分级之间的相关性。结果:828例中97.7%的患者有HBV感染,其中70.9%的患者伴有不同程度的肝纤维化。HCC患者中肿瘤大小与白蛋白(ALB)、球蛋白(GLB)、白球比(ALB/GLB)、天冬氨酸转氨酶(AST)、AST/ALT、γ-谷氨酰转移酶(GGT)、碱性磷酸酶(ALP)、α-岩藻糖苷酶(AFU)、甲胎蛋白(AFP)、肿瘤分级多项指标有相关性,肿瘤的病理分级(分化程度)与前白蛋白(PALB)、GGT、肿瘤大小有相关性(P<0.05)。结论:HCC进展与临床实验室多项生化,肿瘤、病毒指标存在相关性,综合应用这些指标对HCC的辅助诊断价值值得进一步研究。

Objective：To retrospectively analyze the routine clinical laboratory parameters for hepatocellular carcinoma, in an attempt to search for parameters for diagnosis of hepatocellular carcinoma（HCC）. Methods： The pre-operation clinical laboratory data, such as tumor makers, and serological biochemical indices, hepatitis B virus （HBV） infection markers, and HBV DNA titers, were collected from 828 patients who were pathologically diagnosed as having HCC; then the correlation between these data with tumor size and the pathological grades of HCC was analyzed. Results：It was found that 97.9% of the 828 patients were infected with HBV and 70.9% of them were accompanied by liver fibrosis. We also found that the tumor size was correlated with albumin （ALB）, globulin （GLB）, A/G, aspartate aminotransferase （AST）, ratio of aspartate to alanine aminotransferase （AST/ALT）, gamma-glutamyl transferase （GGT）, alkaline phosphatase （ALP）, alpha-L-fucosidase （AFU）, alpha-fetoprotein （AFP） and tumor grades; meanwhile, the pathological grades of tumor was correlated to prealbumin（PALB）, GGT and tumor size（all P〈0.05）. Conclusion： The progress of HCC is correlated with several clinical laboratory biochemistry indices and virus indices. The combined application of these indices is worth studying for auxiliary diagnosis of HCC.