肾血管性高血压大鼠模型中ET_1和CGRP的变化

Effect of Calcitonin Gene-Related Peptide and ET_1 on Rat Model of Renovascular Hypertension

目的探讨降钙素基因相关肽(CGRP)及血浆内皮素(ET1)在高血压病中的作用。方法选用正常血压大鼠42只,随机分对照组、手术组、假手术组,分别观察血压值、CGRP及ET1值。结果手术组与正常组比较血压明显高于正常对照组(P<0.01),假手术组与正常对照组比较,血压无明显变化(P>0.05);手术组与对照组比较CGRP显著升高(P<0.01);假手术组与正常对照组比较,CGRP未见升高(P>0.05)。手术组与对照组比较ET1无明显变化(P>0.05)。结论CGRP在肾血管性高血压的发生发展中具有保护作用。ET1与CGRP是心血管系统中的一对拮抗因子,与CGRP的作用相反,ET1有较强的缩血管作用,从而导致血压升高。

Objective To explore the effect of calcitonin gene-related peptide （CGRP） and ET1 on hypertension. Methods 42 rats with normal blood pressure were randomly divided into operation, sham operation and control groups. The level of CGRP and ET1 were determined at 2,4,6,8 and 10 weeks after treatment,respectively. Results The blood pressure in rats of the operation group was significantly higher than that in the control group （ P 〈 0.01 ）, but there was not significant difference between that of rats in the sham operation and normal control groups. CGRP of the operation group was significantly higher than that of control group （ P 〈 0.05）. ET1 of the operation group was significantly higher than that of control group. No significant difference was found between the ET1 and CGRP in the sham operation group and control group. Conclusion CGRP has a protective effect on blood vessels in renal arterial hypertension, but ET1 exerts a vasoconstrictive action.