巴洛沙星对泌尿道病原菌的体外抗菌活性

Antibacterial activity of balofloxacin against urinary tract pathogens in vitro

目的:评价巴洛沙星对泌尿道病原菌的体外抗菌活性。方法:收集泌尿道感染病人尿液中所分离到的249株病原菌,其中革兰阳性菌90株(金黄色葡萄球菌30株、表皮葡萄球菌27株、粪肠球菌18株、B溶血性链球菌15株)、革兰阴性菌159株(大肠埃希菌84株、肺炎克雷伯菌20株、肠杆菌属25株、奇异变形杆菌15株、铜绿假单胞菌15株),采用琼脂二倍稀释法,测定巴洛沙星与左氧氟沙星对该249株泌尿道病原菌的最低抑菌浓度(MIC)。结果:巴洛沙星对革兰阳性菌的MIC_(90)(2～8 mg·L^(-1))是左氧氟沙星MIC_(90)(2～16 mg·L^(-1))的1/4～1/2或相等,对革兰阴性菌的MIC_(90)(4～32 mg·L^(-1))是左氧氟沙星MIC_(90)(2～16 mg·L^(-1))的2～4倍或相等。结论:巴洛沙星对革兰阳性菌和革兰阴性菌均具有抗菌活性,其中对革兰阳性菌的作用稍强于或等于左氧氟沙星,对革兰阴性菌的作用等于或稍弱于左氧氟沙星。

AIM： To evaluate the antibacterial activity of balofloxaein against urinary tract pathogens in vitro. METHODS： Two hundred and forty-nine bacterial tribes were collected from the urine of urinary tract infection patients, including 90 gram-positive bacteria （30 Staphylococcus aureus, 27 Staphylococcus epidermidis, 18 Enterococcus faecalis, 15 Streptococcus β haemolyticus ） and 159 gram-negative bacteria （84 Escherichia coli, 20 KlebsieUa pneumoniae, 25 Enterobacter spp, 15 Proteus mirabilis, 15 Pseudomonas aeruginosa） . The minimum inhibitory concentration （MIC） of balofloxaein and levofloxaein against 249 pathogens of urinary tract infections was determined by agar dilution method. RESULTS ： MICgo of balofloxaein （2 - 8 mg·L^-1） was 1/4 - 1/2 or equal to that of levofloxaein （2 -16 mg·L^-1） in antagonizing gram-positive bacteria. MICgo of balofloxaein （4 - 32 mg·L^-1） was 2 - 4 times or equal to that of levofloxaein （2 ~ 16 mg·L^-1）in treating gram-negative bacteria. CONCLUSION： Balofloxacin possesses antibacterial activity against grampositive and gram-negative bacteria. Balofioxacin is more powerful than or equal to that of levofloxacin in treating gram-positive bacteria, but less than or equal to that of levofloxacin for gram-negative bacteria.