胰腺星状细胞在胰腺腺癌进程中的作用及机制
摘要
胰腺癌主要为胰腺导管腺癌，其发病率与病死率接近，5年存活率不到5％。病理检查显示，胰腺腺癌往往有显著增加的纤维组织增生，胰腺星状细胞（PSCs）是分泌细胞外基质的效应细胞，但在胰腺腺癌进程中可能起的作用尚未完全清楚，现将PSCs与胰腺癌的关系做一综述。
出处
《胰腺病学》
2007年第6期419-420,共2页
Chinese JOurnal of Pancreatology
参考文献15
-
1Jemal A, Siegel R, Ward E,et al. Cancer statistics, 2007. CA Cancer J Clin, 2007,57 : 43-66.
-
2Koninger J, Giese T, di Mola FF,et al. Pancreatic tumor cells influence the composition of the extracellular matrix. Biochem Biophys Res Commun, 2004,322:943-949.
-
3Binkley CE, Zhang L, Greenson JK, et al. The molecular basis of pancreatic fibrosis: common stromal gene expression in chronic pancreatitis and pancreatic adenocarcinoma. Pancreas, 2004,29:254-263.
-
4Ellenrieder V, Alber B, Lacher U, et al. Role of MT-MMPs and MMP-2 in pancreatic cancer progression. Int J Cancer, 2000,85:14-20.
-
5Schneiderhan W, Diaz F, Fundel M, et al. Pancreatic stellate cells are an important source of MMP-2 in human pancreatic cancer and accelerate tumor progression in a murine xenograft model and CAM assay. J Cell Sci,2007,120:512-519.
-
6Zhang W, Erkan M, Abiatari I, et al. Expression of extracellular matrix metalloproteinase inducer (EMMPRIN/ CD147) in pancreatic neoplasm and pancreatic stellate cells. Cancer Biol Ther, 2007,6 : 218-227.
-
7Bachem MG, Schunemann M, Ramadani M, et al. Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology, 2005,128 : 907-921.
-
8Yoshida S, Yokota T, Ujiki M, et al. Pancreatic cancer stimulates pancreatic stellate cell proliferation and TIMP-1 production through the MAP kinase pathway. Biochem Biophys Res Commun, 2004,23 : 1241-1245.
-
9Yoshida S, Ujiki M, Ding XZ, et al. Pancreatic stellate cells (PSCs) express cyclooxygenase-2 ( COX-2 ) and pancreatic cancer stimulates COX-2 in PSCs. Mol Cancer, 2005,4:27.
-
10Esposito I, Penzel R, Chaib-Harrireche M, et al. Tenascin C and annexin Ⅱ expression in the process of pancreatic carcinogenesis. J Pathol, 2006,208 : 673-685.
-
1杨伟峰,陈厚昌,李琳.姜黄素对肝星状细胞增殖及分泌细胞外基质的影响[J].临床肝胆病杂志,2004,20(3):142-143. 被引量：13
-
2余盼攀,季世强,张胜初,向俊峰,张启瑜.白细胞介素-17对大鼠肝星状细胞MMP-2和TIMP-1表达的影响[J].中华实验外科杂志,2011,28(12):2130-2130.
-
3A.S.Epstein,黄伟,赵红川.一个单独机构(MSKCC)关于胰腺外分泌癌患者合并血栓栓塞的发病率及临床预后的分析[J].肝胆外科杂志,2010,18(4):319-319.
-
4贺杰.免疫性胰腺炎与胰腺腺癌的CT鉴别诊断[J].深圳中西医结合杂志,2014,24(5):50-51.
-
5杨伟峰,陈厚昌,夏笔军.丹参酮ⅡA对肝星状细胞增殖及分泌细胞外基质的影响[J].实用医学杂志,2003,19(11):1191-1192. 被引量：22
-
6施贵静,赵金满.γ-干扰素对肝星状细胞分泌细胞外基质影响的研究[J].丹东医药,2008(1):2-6.
-
7刘亚君.降糖治疗影响胰腺癌的发生[J].山东医药,2009,49(32):116-116. 被引量：2
-
8杨伟峰,卢放根,刘凌云.姜黄素与阿米洛利联用对肝星状细胞增殖及分泌细胞外基质的影响[J].中华消化杂志,2006,26(4):259-260. 被引量：1
-
9胡佳佳,李淑德,高军.Hedeghog信号通路与胰腺癌治疗研究进展[J].中华胰腺病杂志,2014,14(1):66-69. 被引量：1
-
10汪明明,崔速南,李新立,杨公炜,杜文军.结缔组织生长因子的肝内表达与肝纤维化的关系[J].中华传染病杂志,2006,24(3):202-204. 被引量：5
