摘要
目的研究黄芪多糖对糖尿病大鼠肾脏的保护作用。方法以链脲佐菌素(STZ)诱导产生糖尿病大鼠模型,将模型大鼠随机分为糖尿病模型组及黄芪多糖组,另设正常对照组,连续灌胃4wk。观察治疗后大鼠体重、血糖、尿微量白蛋白排出量及肾皮质Na+,K+-ATPase活性的改变。结果糖尿病组大鼠体重明显下降,血糖显著升高,尿微量白蛋白排出量增加,肾皮质Na+,K+-ATPase活性增加;黄芪多糖治疗后,体重增加,血糖降低,尿微量白蛋白排出量减少,肾皮质Na+,K+-ATPase活性增加受抑制。结论黄芪多糖对糖尿病肾脏病变有防治作用,对肾脏有保护作用。
objective To investigate the effect of astragalus polysaccharides (APs) on renal lesions in diabetic rat. Methods the rats were randomly divided into three groups:the diabetic rat model without treatment (DM) , diabetic rat model with astragalus polysaecharides treatment and the normal control, the treatment lasted for 4 weeks. Results Compared with that of control groups in diabetic group, the body weight decreased significantly, The fasting blood glucose had a remarkable increase, Alb132-MG level in urine and kidney cortex Na^+,K^+-ATPase activity increased remarkably. However, all of the indexes in astragalus polysaccharides treated group changed oppositely. Conclusions Astragalus polysaccharide has some improving effects on the kidney of diabetic rat.
出处
《遵义医学院学报》
2007年第3期243-244,247,共3页
Journal of Zunyi Medical University