重组人生长激素对局灶性脑缺血大鼠神经功能恢复的影响

Effects of the recombinant human growth hormone on recovery of nervous function with focal cerebral ischemia in rats

目的:研究重组人生长激素(recombinanthu-mangrowthhormone,rhGH)对大鼠局部脑缺血损伤后的影响。方法:应用线栓法制作SD大鼠大脑中动脉永久性闭塞模型(middlecerebralarteryocclusion,MCAO),观察rhGH对大鼠脑缺血后脑梗死面积和神经功能(网屏试验、平衡木试验、触觉刺激试验)恢复的情况。结果:皮下注射rhGH后,药物干预组大鼠脑梗死体积较缺血对照组明显减小(P<0.05),神经功能恢复水平高于自然恢复组。结论:rhGH能减轻大鼠脑缺血MCAO后的脑实质和神经功能损伤。

AIM： To investigate the effects of the recombinant human growth hormone （rhGH） on the recovery of nervous function with focal cerebral ischemia in rats. METHODS： The middle cerebral artery occlusion （MCAO） model was established by insertion of nylon thread in SD rats. The rhGH was given to the rats in the rhGH-treated group. The infarct size and recovery of nervous function were observed after MCAO. RESULTS： The infarct size in the rhGH-treated group （29 ±5）% was obviously smaller than that in the simple ischemia group （36 ± 4）%. The recovery of nervous function in the rhGH-treated group was much better than that in the simple isehemia group. CONCLUSION： It is manifested that the rhGH can significantly reduce the injure of brain tissue and recover nervous function caused by cerebral infaretion.