肺癌性病灶的同层动态CT净增值与MVD相关性研究

The Study on the Correlation between Dynamic Enhanced Increased CT value and MVD of Lung Cancer

目的探讨肺癌性病灶同层动态CT净增值与微血管密度（MVD）的相关性。资料与方法选取周围型肺癌31例，其中腺癌24例（包括细支气管肺泡癌8例），鳞癌7例。病灶直径1．0～6．5cm，平均2．6cm，其中≤3cm者24例，〉3．1cm者7例。常规先行病灶同层动态CT增强扫描，获取手术后肿瘤大体病理标本和结果，再行CD34抗体的MVD的免疫组织化学测定。结果（1）31例肺癌的同层动态CT净增值和MVD之间具有显著相关性（r=0．753，P〈0．05）。（2）肺癌的最大CT净增值与组织学类型有关：腺癌的最大CT净增值和MVD值均明显高于鳞癌（P〈0．05）。（3）肺癌最大CT净增值和MVD值与肿瘤大小有关：直径≤3cm者高于〉3．1cm者。结论肺癌性病灶的同层动态CT净增值与MVD有相关性，可作为评价肿瘤血管生成的指标。

Objective To investigate the relationship between dynamic enhanced increased CT value and MVD （micro vascular density） of lung carcinoma. Materials and Methods 31 cases of peripheral lung carcinoma （ adenocarcinoma in 24 cases and squamous carcinoma in 7 cases） confirmed by surgery were performed with dynamic enhanced CT, and immunohistochemiacal stain of anti CD 34 antibody was measured in specimen. The diameter of lesions was 1.0 - 6.5 cm, mean 2.6 cm （including diameter ≤3 cm in 24 cases and 〉 3.1 cm in 7 cases）. Results （ 1 ） There was a linear positive correlation between the max increased CT value and MVD in 31 cases with peripheral lung carcinoma（r=0. 753 ,P 〈0.05）. （2）Both of the max increased CT value and MVD of lung adenocarcinoma were higher than that of squamous carcinoma, （ P 〈 0.05）. （3） Both of the max of CT value and MVD of lung cancer with the diameter ≤3.1 cm were higher than that of 〉3.1 cm（P =0. 017）. Conclusion There is positive correlation between the max increased CT value and MVD in peripheral lung carcinoma, max increased CT value and MVD can provide information for lung carcinoma angiogenesis.