利多卡因对兔胰管远端括约肌压力影响的研究

Effects of Lidocaine on the Pancreatic Sphincter Pressure of Rabbits

目的:研究利多卡因对兔胰管远端括约肌压力的影响。方法:18只日本大耳兔随机分为利多卡因组、蒸馏水组和对照组,每组6只。开腹后在兔胰管远端括约肌周围分别喷洒利多卡因或蒸馏水,之后进行括约肌的压力测定。结果:利多卡因在胰管远端括约肌的乳头部喷洒,可以明显降低括约肌压力,与蒸馏水乳头部喷洒比较,括约肌压力的改变差异有统计学意义,P<0.05;喷洒蒸馏水组与单纯测压组比较,括约肌的压力没有显著差异,P>0.05。结论:利多卡因在胰管远端括约肌的乳头部喷洒,可以明显降低括约肌压力。

To explore the effect of hdocaine on the pancreatic sphincter pressure of rabbits. Methods： Eighteen rabbits were randomly divided into 3 groups （6 in each）：1） Rabbits were sprayed around the pancreatic sphincter with 5ml of lidocaine ; 2 ） Rabbits were sprayed with 5ml of distilled water instead; and 3 ） Rabbits were not sprayed any liquid. The pressures of pancreatic sphincter of all the rabbits were measured after the abdomen opening and the spraying of lidocaine or water. Results： The pancreatic sphincter pressure of rabbits in group 1 was significantly lower than those of rabbits in groups 2 and 3 （ P 〈 0.05 ）. There was no significant difference between those of rabbits in groups 2 and 3 （ P 〉 0.05 ）. Conclusion： Lidocine sprayed on pancreatic papilla can significantly reduce pancreatic sphincter pressure.