摘要
讨论了浸透限制固定相的特性及其在药物分析中的应用。已发展起来的浸透限制固定相主要用于高效液相色谱法对生物体液中药物的直接进样分析。这种固定相填料是在疏水层上覆盖了一层亲水层，而亲水层允许小分子物质如药物自由出入于固定相的疏水部分，从而立体地阻止了大分子物质如蛋白质与固定相的疏水部分相互作用，使小分子物质得到分离。该固定相包括内表面反相、半透表面。
Several types of restricted access stationary phases used for the analysis of drugs in biological fluids by direct injection into high performance liquid chromatographic column are introduced in this paper with 20 references.These new packings included internal surface reversed phase,semipermeable surface,shielded hydrophobic phase and mixed functional phase.The structural characteristics and the chromatographic properties of these packings are reviewed,especially with regard to their use in the assaying of drugs.
出处
《色谱》
CAS
CSCD
北大核心
1997年第1期33-35,共3页
Chinese Journal of Chromatography
关键词
高效液相色谱
浸透限制固定相
体液
药物
high performance liquid chromatography, restricted access stationary phases, drugs in biological fluids
