药物引起色素沉着126例文献分析

Analysis of 126 Cases of Drug-induce reaction of hyperpigmentation

目的:探讨药物引起色素沉着的特点及一般规律。方法:对1994年1月—2006年12月国内医药学术期刊报道的药物引起的色素沉着126例文献进行统计和分析。结果:药物引起的色素沉着可出现在给药过程中,也可以出现在连续用药后;引起色素沉着的药物种类以抗感染药和中药制剂居多。结论:临床应重视药物引起的色素沉着,以确保用药安全。

OBJECTIVE To discuss the general regularity and characteristics of drug - induced hyperpigmentation. METHEDS 126 eases of drug - induced hyperpigmentation reported in internal medical journals published from Jan. 1994 to Dec. 2006 were collected and analyzed. RESULTS The onest of hyperpigmentation occurred in the process of administer, or a few days after the medication. The drugs that induced hyperpigmentation were chiefly Anti - infectives drugs and Chinese drugs pharmaceutics. CON- CLUSION：To ensure medication safety,attention should be given to the drugs induced hyperpigmentation for clinical pharmacists.