Listerine~漱口水抑制牙菌斑再生效果的临床研究

Inhibitory Effect of Listerine~ Mouthwash on the Re-growth of Dental Plaque in Vivo

目的：观察Listerine漱口水体内抗菌斑的效果。方法：按纳入标准在武汉大学学生志愿者中随机抽取20人（20～25岁）。实验期间，依据双盲、自身对照的原则，每一个受试者分别随机先后含漱Listerine漱口水（试验组）、安慰剂（阴性对照组）、0．12％氯已定含漱液（阳性对照组）。每种漱口水使用4d，期间停止一切口腔清洁措施。4d后，采用改良Qiugley—Hein菌斑指数记录法，记录PLI值。中间间隔10d，再使用另一种漱口水。应用SPSS14．0统计软件，采用单因素方差分析各组PLI值，非参数检验分析各组漱口水副反应差异。结果：在抑制牙菌斑形成方面Listerine漱口水与安慰剂相比较，有显著性统计学差异（P〈0．001），但不及氯已定漱口水（P〈0．05）。氯已定含漱液易引起味觉的改变，口味满意程度也差于Listerine漱口水（P〈0．05）。结论：Listerine漱口水在抑制牙菌斑形成方面有一定的效果，且副反应小。

Objective： To observe the effect of Listerine mouthrinse on controlling the re -growth of dental plaque. Methods： The controlled clinical study was a double - blinded, randomized, three replicate cross - over design. 20 healthy volunteers of Wuhan University （20 -25 years old） refrained from all oral hygiene measures, but rinsed with Listerine mouthtinse, 0. 12% chlorhexidine gluconate or placebo individually at random. Plaque index was assessed after four days. After a 10 - day wash - out period, a new test cycle was started. ANOVA was used to analysis the effect of mouthrinse on the 4 - day plaque re - growth. Nonparametric tests were used to analyse the adverse effect of different kinds of mouthwash. Results： The significant statistical difference was found between Listerine mouthrinse and placebo （ P 〈 0. 001 ）. The efficacy of 0.12% chlorhexidine gluconate on controlling the re - growth of dental plaque was better than Listerine mouthrinse（P 〈 0.05）, but it had more adverse effect than Listerine in taste （P 〈0.05 ）. Conclusion： Listerine mouthrinse on controlling the re - growth of dental plaque was effective. It had minor adverse effect.