皮内植线疗法治疗经前期综合征肝气逆证的随机对照研究

Random Comparison on the Therapeutic Effects of Hypodermic Catgut Embedding to Treat Premenstrual Syndrome with Invasion of the Hyperactive Liver-qi

目的:观察皮内植线疗法辨证取穴治疗经前期综合征肝气逆证(PMS)的临床疗效。方法:将108例PMS患者,随机分为治疗组和对照组各54例,治疗组采用皮内植线疗法辨证取穴治疗,对照组采用口服药物对症治疗,两组均连续治疗3个月经周期,治疗后随访3个月经周期统计疗效。结果:纳入108例患者,105例完成试验,脱落3例。治疗组和对照组总有效率(ITT/PP)分别为92.6%/94.3%、75.7%/78.8%;治疗组:临床痊愈35/35,显效9/9,好转6/6,无效4/3;对照组:临床痊愈5/5,显效17/17,好转19/19,无效13/11;ITT和PP分析结果一致:治疗组的综合疗效以及痊愈患者显著优于对照组(P<0.01);两组治疗前后症状评分、汉密尔顿焦虑量表比较差异有极显著意义(P<0.001),以治疗组更好(P<0.001);治疗组较对照组快捷持久(P<0.05)。结论:皮内植线疗法采用辨证取穴的方法治疗PMS具有高效快捷、安全无痛的特点,临床疗效优于口服药物对症治疗,值得临床推广应用。

Objective： To evaluate the therapeutic effects of hypodermic catgut embedding for treating premenstrual syndrome （PMS） with invasion of the hyperactive Liver-qi.Methods： A total of 108 PMS patients were randomly divided into two groups of 54： the treatment group and the control group.The treatment group adopted the method of hypodermic catgut embedding, and the control group used oral medroxyprogesterone acetate tablets, estazolam tablets and bromocriptine mesylate tablets. Both groups were treated for three menstrual periods continually. The therapeutic effects were evaluated after 3 periods of follow-up check. Results： Among the 10s patients, 10s completed the treatment, and the other 3 withdrew from the treatment.The ITT/PP analysis indicated that the total efficiencies of the treatment group and control group were 92.6%/94.3%, and 75.7%/78.8% .As for the treatment group, there were 35/35 cured clinically, 9/9 remarkably effective, 6/6 effective and 4/3 ineffective.The corresponding numbers in the control group were 5/5, 17/17, 19/19 and 13/11 .The analysis results were consistent according to the methods of ITT and PP respectively： the comprehensive effects in the treatment group were obviously better than that of the control group, and the number of patients cured in the treatment group was obviously higher than that of the control group （P 〈 0.01） .The difference comparison of symptom evaluation and Hamilton anxiety scale before and after the treatment were of profound significance （ P 〈 0. 001 ）, and the treatment group showed a better result （ P 〈 0.001 ） . The therapeutic effects of the treatment group were shown quicker and longer. Conclusion： Clinical therapeutic effects of hypodermic catgut embedding to treat PMS are better than those of oral administration of medroxyprogesterone acetate tablets, estazolam tablets and bromocriptine mesylate tablets. It is highly efficient, comparatively safe and pain-free. As a result, it is worthy of application in clinic practice.