视网膜神经保护因子的研究进展

PROGRESS OF RESEARCH IN RETINA NERVE PROTECTIVE FACTOR

各种原因造成的视网膜完全或部分缺血,可导致视网膜节细胞(RGC)的死亡和神经纤维数量的减少,这是造成视功能不可逆损害的主要病理基础。近几年大量的研究表明,许多蛋白和因子对视网膜神经元的保护起重要的作用,如:热激蛋白(HSP)、脑源性神经营养因子(BDNF)、肝细胞生长因子(HGF)等能减轻急性高眼压或急性视网膜缺血对RGC和视神经纤维所造成的损害,对神经元的保护起重要作用。本文对视网膜神经保护因子的研究进展简要作一综述。

The death of retinal ganglion cells（RGC） and the decreasing of retinal nerve fiber are resulted from the complete or partial retina ischemia. It is the major pathological elements that can make permanent damage of the vision function. Recently, lots of research made us clear that many proteins and cytokines can protect the retinal nerve fiber such as HSP, BDNF and HGF. This paper briefly summarize related developmet of investigations.