小剂量肝素与拉米夫定联合治疗肝炎后肝硬化33例

Report of 33 hepatic cirrhosis patients caused by chronic hepatitis B treated with low-dose heprin and Lamivudine

目的观察小剂量肝素与拉米夫定联合治疗慢性乙型肝炎所致的失代偿性肝硬化的疗效。方法病人在综合护肝治疗的基础上分三组，对照1组给予常规综合护肝对症治疗，对照2组在综合治疗的基础上加用拉米夫定，治疗组加用小剂量肝素与拉米夫定。结果治疗组在2mo后，除ALT外，其ALB、TBil、HBV DNA和Child-pugh计分与对照1、2组均有显著性差异（P〈0．05）。结论小剂量肝素与拉米夫定联合治疗慢性乙型肝炎失代偿性肝硬化，可显著消退黄疸，提高白蛋白，改善Child—pugh计分。

Objective To observe the therapeutic effects of low-dose heparin combined with Lamivudine in curing decompensate hepatic cirrhosis caused by chronic hepatitis B. Methods The patients are allotted to three groups based on combined liver protecting therapy, the control group 1 is applied with routine liver protecting therapy, the control group 2 is added with Lamivudine, and the curing group is applied with low-dose heparin combined with Lamivudine. Results After 2 months, beside ALT, the ALB, Tbil, HBV DNA and Child-pugh of curing group are significant different with the control group 1 and 2 （P〈0.05） . Conclusions It can obviously decrease the jaundice, elevate albumin level, and improve Child-pugh score difference to apply low-dose heparin combined with Lamivudine to cure decompensate hepatic cirrhosis caused by chronic hepatitis B.