C反应蛋白与老年冠心病患者颈动脉病变及冠状动脉钙化的关系

Serum C-reactive protein is positively correlated with pathological changes of carotid artery and coronary calcification in elderly patients with coronary artery disease

目的通过对老年冠心病患者血清C反应蛋白(CRP)检测,颈动脉内膜中层厚度的测定,冠状动脉钙化积分的测定来探讨冠心病患者颈动脉粥样硬化程度与冠状动脉病变的相关性。方法96例老年冠心病患者分别检测血浆CRP值、颈动脉超声和螺旋CT冠状动脉钙化积分,观察颈动脉内膜中层厚度(IMT)与CRP关系;不同级别颈动脉斑块与CRP的关系;以及颈动脉不同级别斑块与冠状动脉钙化积分关系。结果血清CRP随着IMT的增加而升高(P<0.05),血清CRP随着颈内动脉斑块级别的增加而升高(P<0.05)。颈动脉内膜中斑块级别越高,检出冠状动脉钙化积分值越高(P<0.05)。结论CRP不仅与冠状动脉粥样硬化程度成正比,与颈内动脉斑块的范围及严重程度也成正比。老年冠心病患者颈动脉粥样硬化程度与冠状动脉病变程度相一致。

Objective To see whether there is any correlation between C-reactive protein （CRP） and pathological changes of carotid artery and coronary calcification in elderly patients with coronary artery disease （CAD） by determination of CRP, e.arotid intima-media thickness （IMT） and coronary calcification index （CCI）. Methods Serum CRP in different IMT and different plaques in the carotid artery and CCI were measured and analyzed in 96 CAD old patients. Results The higher the serum CRP was, the greater the IMT （P〈0.05）, the higher the grade of the plaque in the carotid artery （P〈0.05）, and the higher the CCl （P〈0.05）. Conclusions Serum CRP is not only positively e.orrelated with the degree of coronary atheroselerosis but with the extent of plaques in the carotid after. The degree of carotid atheroselerosis is consistent with coronary calcification in elderly CAD patients.