人羊膜对糖尿病患者创面愈合的促进作用

Fresh Human Amnion Promotes Wound Healing in Diabetic Patients

目的探讨局部应用新鲜人羊膜(以下简称羊膜)对糖尿病创面愈合的治疗作用。方法选择有难愈性创面的糖尿病患者120例,采用随机数字表法将患者分为观察组和对照组各60例,观察组局部创面应用新鲜羊膜覆盖治疗,对照组采用常规换药法,分别于第3、7、14天比较两组患者的创面愈合情况(包括上皮葡行面积及肉芽成熟程度)。结果两组糖尿病患者的局部创面在第3天无明显变化;第7、14天,观察组局部创面的上皮葡行速度及肉芽组织生长均明显优于对照组(P<0.05,P<0.01)。结论局部应用羊膜能从多方面促进糖尿病患者创面的愈合,建议在临床推广使用。

Objective To observe the efficacy of fresh human amnion in promoting wound healing in diabetic patients. Methods The total of 120 diabetic patients with wounds were randomly divided into 2 groups, namely the amnion group with wound dressing using fresh human amnion, and the control group with routine wound dressing. The wound healing （epidermal coverage of the wound surface and maturity of the granulation tissue） was assessed 3, 7, and 14 days after wound dressing. Results No obvious difference was found between the two groups in wound healing on the third day, but on days 7 and 14, greater epidermal coverage of the wound surface and maturity of the granulation tissue were observed in wounds with amnion application than in those with routine wound dressing. Conclusion Local application of fresh human amnion can promote the healing of the wound surface in diabetic patients.