血清S100B蛋白与新生儿窒息后脑损伤的关系

The relationship between serum S100B protein and brain damage following neonatal asphyxia

目的探讨窒息新生儿脐血及生后血清S100B蛋白动态改变及S100B蛋白与新生儿窒息后脑损伤之间的关系。方法对40例窒息新生儿(窒息组)及40例正常新生儿(对照组)脐血及生后第1、3、7天血清S100B蛋白变化进行分析,生后第3￣5天对窒息儿进行头颅CT检查。结果(1)窒息组脐血S100B蛋白含量明显高于对照组,差异具有统计学意义(P<0.05),轻度窒息与重度窒息新生儿脐血S100B蛋白含量差异无统计学意义(P>0.05)。(2)生后第1￣7天内轻度窒息患儿血清S100B蛋白无明显改变(P>0.05),重度窒息患儿血清S100B蛋白呈逐渐升高趋势(P<0.01),生后第7天重度窒息患儿血清S100B蛋白明显高于轻度窒息患儿(P<0.01)。(3)头颅CT检查阳性的患儿生后第3天血清S100B蛋白含量显著高于CT检查阴性患儿(P<0.01)。结论血清S100B蛋白检测有助于新生儿窒息后脑损伤的判断。

Objective To investigate the relationship between SIOOB protein and brain damage following neonatal asphyxia. Methods Forty newborn infants with asphyxia （asphyxia group） and 40 normal newborn infants （control group） were enrolled in this study. The cord blood and serum S100B protein levels were measured on day 1, 3, 7 after birth. Cranial computed tomography （CCT） was performed in asphyxia group from 3 to 5 d after birth. Results Mean cord blood S100B protein levels in the asphyxia group were significantly higher than those in the control group （P〈0.05）, but there was no staffstical difference between neonates with mild asphyxia and those with severe asphyxia （P〉0.05）. The serum SIOOB protein levels had no statistical difference in the infants with mild asphyxia on days 1-7 after birth （P〉0.05）. But serum SIOOB protein of infants with severe asphyxia complicated by brain damage increased progressively and was significantly higher than those with mild asphyxia on day 7 （P〈0.01）. The serum S100B concentration of CCT positive infants was significantly higher than those in CCT negative infants. Conclusion Serum SIOOB protein level might be a valuable index for the diagnosis of neonatal asphyxia following brain damage.