摘要
作者全面系统地阐述了近年来抗艾滋病新药的研发策略和研究进展,并根据药物作用靶点分别介绍了新上市的抗艾滋病药物的作用机制和结构特点,如第二代HIV-1逆转录酶抑制剂和HIV-1蛋白酶抑制剂,以及全新作用机制的HIV-1进入抑制剂和HIV-1整合酶抑制剂,并对今后抗艾滋病药物的发展方向进行了展望。
In this review the new strategies and development in the drug discovery of anti-HIV therapy are comprehensively reported, and the novel meehanism of aetion and the struetures of newly FDA-approved anti-AIDS drugs aecording to the targets are introduced. The future direction of development of the anti-HIV agents is briefly diseussed.
出处
《药学服务与研究》
CAS
CSCD
2007年第6期401-407,共7页
Pharmaceutical Care and Research
