依达拉奉联合高压氧辅助治疗急性脑梗死42例

Intravenous Edaravone Combined with Hyperbaric Oxygen for Treatment of 42 Cases of Acute Cerebral Infarction

目的观察依达拉奉联合高压氧辅助治疗急性脑梗死的临床疗效。方法选择发病24 h内的急性脑梗死患者82例,随机分为联合治疗组42例和对照组40例。联合治疗组应用依达拉奉静脉给药,剂量为30 mg,bid,共14 d,48 h内开始联合高压氧治疗,每次60 min,qd,共12次,压力为2.5个绝对大气压(ATA)。其余治疗与对照组相同。治疗前,治疗后7,14及21 d对患者进行欧洲卒中量表(ESS)评估。结果两组治疗后7,14及21 d与治疗前比较神经功能评分ESS均有明显改善。联合治疗组神经功能评分ESS在治疗后7 d与对照组比较差异无显著性(P>0.05),在治疗后14 d优于对照组,差异有显著性(P<0.05),在治疗后21 d优于对照组,差异有极显著性(P<0.01)。结论依达拉奉联合高压氧辅助治疗急性脑梗死,对脑组织有显著保护作用。

Objective To investigate the effects of intravenous edaravone combined with hyperbaric oxygen on acute cerebral infarction. Methods 82 cases of acute cerebral infarction （ACI）, enrolled within 24 h of onset, were randomly divided into the combined treatment group （42 cases） and control group （40 cases）. Edaravone was infused at a dose of 30 mg, twice a day, for 14 days. Hyperbaric oxygen[ 2.5 atmospheres absolute （ATA） for 60 minutes per day ] was initiated within the first 48 hours and repeated daily for 12 days. Whereas the control group received only conventional treatment. We assessed European Stroke Scale（ESS） before and after treatment. Results Early improvement （ day 0 and day 14） , defined as change in European Stroke Scale （ ESS）, was seen among the combined treatment group than in the control group. Further efficacy was seen at day 21. Conclusion The results suggest that edaravone combined with hyperbaric oxygen be effective in patients with acute cerebral infarction .