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乙基纤维素载药纳米粒的制备与体外性能研究 被引量:6

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摘要 目的用乙基纤维素制备环丙沙星纳米粒,并对其进行体外释放性能的测定。方法以环丙沙星为主药,乙基纤维素为主要辅料,采用液中干燥法制备环丙沙星纳米粒,并用透析法进行体外释放度的测定。结果纳米粒平均粒径为690 nm,载药量(33.90±0.54)%,包封率(90.40±0.48)%,在105 h后药物体外释放达到86.38%。结论采用乙基纤维素制备的环丙沙星纳米粒具有明显的缓释效果。
出处 《医药导报》 CAS 2007年第7期789-790,共2页 Herald of Medicine
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参考文献5

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