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急性冠脉综合征患者氧化低密度脂蛋白凝集素样氧化低密度脂蛋白受体-1的水平变化 被引量:7

Levels of the serum ox-LDL,LOX-1 in the patients with acute coronary syndrome
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摘要 目的观察不同类型冠心病患者血中氧化低密度脂蛋白(ox-LDL)、凝集素样氧化低密度脂蛋白受体-1(LOX-1)水平的变化及其之间的关系,探讨临床预测急性冠脉综合征(ACS)的血清学指标。方法采用酶联免疫吸附法测定40例冠心病患者[ACS20例、稳定型心绞痛(SAP)20例]、20例非冠心病患者血清ox-LDL、LOX-1的变化。结果ACS患者外周血清总胆固醇(TC)、低密度脂蛋白(LDL)、ox-LDL、LOX-1水平均高于SAP和非冠心病患者;SAP患者外周血清ox-LDL、LOX-1高于非冠心病患者。ACS患者治疗后ox-LDL、LOX-1水平均低于治疗前。ACS患者LOX-1与ox-LDL呈正相关(P<0.01)。结论ACS患者外周血清ox-LDL、LOX-1水平升高,二者可作为动脉粥样硬化斑块不稳定的血清学指标。 Objective To investigate the serum levels of oxidized low density lipoprotein( ox- LDL), lectin - like oxidized low - density lipoprotein receptor - 1 ( LOX - 1 ) in coronary artery disease of different types and their correlation, and to explore the pathogenesls of acute coronary syndrome (ACS). Methods Enzyme - linked immunosorbent assay was used to measure the ox - LDL, LOX - 1 levels in 40 patients with coronary artery disease (20 with ACS and 20 with stable angina pectoris ) and 20 controis. Results In the patients with ACS, serum TC, LDL, ox -LDL, LOX - 1 levels were significantly higher than those in control group and stable angina pectoris group. In patients with stable angina pecto- ris, ox - LDL and LOX - 1 levels were significantly higher than those in control group. The serum levels of LOX - 1, ox - LDL in the patients with ACS decreased significantly after therapy. Significantly positive correlation between the serum levels of LOX - 1 and ox - LDL was observed in the patients with coronary artery disease. Conclusion Serum ox - LDL, LOX - 1 levels were elevated in ACS patients, which shows the possible relation to the pathogenesis of ACS and may serve as a potential marker of plaque instability.
出处 《中国急救医学》 CAS CSCD 北大核心 2007年第12期1070-1072,共3页 Chinese Journal of Critical Care Medicine
关键词 氧化低密度脂蛋白 凝集素样氧化低密度脂蛋白受体-1 急性冠脉综合征 Oxidized low density lipoprotein ( ox - LDL) Lectin - like oxidized lowdensity lipoprotein receptor - 1 ( LOX - 1 ) Acute coronary syndrome (ACS)
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参考文献6

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二级参考文献11

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