核因子κB抗凝血酶Ⅲ在判断动脉瘤性蛛网膜下腔出血预后中的临床意义

Relationship between level of serum NF-κB,antithrombin Ⅲ and prognosis in subarachnoid hemorrhage

目的对动脉瘤性蛛网膜下腔出血(SAH)患者血浆核因子κB(NF-κB)、抗凝血酶Ⅲ(ATⅢ)水平进行动态观察,研究二者与SAH预后之间的联系。方法收集68例动脉瘤性SAH患者在48h内、第7天、1个月的外周静脉血,采取CSS量表评价患者神经功能,在第7天进行TCD检查。采用发色底物法测定ATⅢ;NF-κB按照武汉博士德生物工程公司提供的SABC试剂盒说明操作,白细胞NF-κB活性用细胞核内棕褐色颗粒的阳性强度积分值表示。结果SAH患者血浆ATⅢ、NF-κB改变与预后有相关性(P<0.05)。结论血浆ATⅢ、NF-κB的变化在判断SAH患者的预后中有一定的临床意义。

Objective To investigate the relationship between level of serum nuclear factor （NF）- κB, antithrombin Ⅲ and prognosis in subarachnoid hemorrhage （SAH）. Methods The peripheral blood samples of 68 SAH patients were collected within 48 hours, the 7th day and 1 month. Blood was drawn to test the antithrombin Ⅲ and NF - κB. Results The levels of NF - κB was significantly higher in the patients with poor outcome than in those with good outcome, but the level of antithrombin m was much lower in patients with poor outcome than in those with good outcome. Conclusion The levels of NF - κB and antithrombin Ⅲ play an important role in the prognosis of patients with SAH.