缺氧诱导因子-1与缺氧缺血性肾损伤

Relationship between hypoxia inducible factor-1 and hypoxic or ischemic kidney injury

缺氧诱导因子-1(hypoxia inducible factor-1,HIF-1)是细胞在缺氧条件下产生的具有转录活性的核蛋白,能与靶基因结合,通过转录和转录后调控使机体对缺氧、缺血产生适应性反应。近年来,HIF-1在肾脏缺氧缺血性损伤中的作用也逐渐受到人们的关注。本文就HIF-1的生物学特点,对靶基因的调节及在缺氧缺血性肾损伤中的作用作一综述。

Hypoxia inducible factor - 1 （ HIF - 1 ） is nucleoprotein with transcriptional activity produced by cells under hypoxic conditions. It can be combined with target genes and regulate its expression at transcriptional or post - transcriptional levels, and consequently adapts to hypoxic or ischemic conditions. In recent years, more attention has been paid to the role of HIF - 1 in injury and disease of kidney. In the article, we make a summary on the HIF - 1＇s biological characteristic, its adjustment to the target genes and its effect on hypoxic or ischemic kidney injury.