鞭毛蛋白在脓毒症并发急性肺损伤中的研究进展

Study of flagellin in acute lung injuries induced by sepsis

鞭毛蛋白是细菌鞭毛的主要成分,是脓毒症发病过程中强有力的前炎性致炎因子,能和TRL5结合并使之活化,激活NF-κB等转录因子,引起多种趋化因子和黏附分子分泌。在健康的志愿者中,血浆中鞭毛蛋白的浓度低于ELISA<0.1μg/mL的检测水平,而在脓毒症的患者中,血浆中鞭毛蛋白的浓度为(7.06±0.14)μg/mL,并且外周血鞭毛蛋白的水平和脓毒症持续的时间、肺损伤的程度、肺泡肺小动脉氧张力差值呈明显的正相关,和白细胞的减少程度也有相关的趋势。

Flagellin, the main component of flagellar filaments, is an extraordinarily potent proinflammatory stimulus in sepsis. Flagellin interacts with TLR - 5 and leads to activation of NF -κB. In healthy human volunteers, plasma flagellin levels were below the detection limit of our ELISA. In the plasma of patients with sepsis, flagellin levels amounts to （7.06 ± 0.14 ）μg/mL. Plasma flagellin levels show a significantly positive correlation with the duration of the sepsis ,the lung injury score as well as the alveolar - arterial oxygen difference. There is also a trend of the correlation between the plasma flagellin concentrations and the degree of leukopenia.