摘要
目的:检测乳腺癌组织中雌激素受体β(ERβ)、C-erbB-2和bcl-2蛋白的表达情况,并分析ERβ蛋白的表达与组织学分级、C-erbB-2及bcl-2蛋白表达的关系。方法:采用免疫组化S-P法检测96例乳腺癌组织标本中ERβ、C-erbB-2及bcl-2蛋白的表达情况,并作统计学分析。结果:96例乳腺癌组织标本中,ERβ、C-erbB-2及bcl-2蛋白阳性表达率分别为64.6%、36.5%和51.0%;ERβ蛋白的表达与组织学分级、C-erbB-2蛋白的表达呈负相关(P<0.05),与bcl-2蛋白的表达呈正相关,与腋淋巴结状态无关(P>0.05)。结论:ERβ蛋白表达可能是乳腺癌患者预后良好的指标。
Objectlve:To detect the expressions of ERβ, C -erbB -2 and bel -2 protein in breast cancer , and analyze the relationship between the expression of ERβ protein and tumor grade, the expression of C - erbB - 2 and bel - 2 protein. Methods: Immunohistochemistry S - P method was used to detect the expression of ERβ, C - erbB - 2 and bcl - 2 protein in 96 breast cancer samples. Rssult of detection were analyzed statistically. Results: The positive expression rates of ERβ, C - efbB -2 and bcl -2 protein were 64.6%, 36.5% and 51.0% respectively;The expression of ERβ protein had a negtive correlation with tumor grade and the expression of C - erbB - 2 protein(P 〈 0.05 ), and had a positive correlation with the expression of bcl -2 protein, no correlation with axillary lymph node status(P 〉 0.05 ). Conclusion: ERβ protein may be a useful marker which predicts good prognosis of breast cancer patients.
出处
《现代肿瘤医学》
CAS
2008年第1期38-40,共3页
Journal of Modern Oncology
基金
安徽省卫生厅科研基金资助项目(2002A038)
关键词
乳腺癌
雌激素受体Β
预后
breast cancer
estrogen receptor beta
prognosis