ERβ、C-erbB-2及bcl-2蛋白在乳腺癌组织的表达及意义

The expression and significance of ERβ,C-erbB-2 and bcl-2 protein in breast cancer

目的:检测乳腺癌组织中雌激素受体β(ERβ)、C-erbB-2和bcl-2蛋白的表达情况,并分析ERβ蛋白的表达与组织学分级、C-erbB-2及bcl-2蛋白表达的关系。方法:采用免疫组化S-P法检测96例乳腺癌组织标本中ERβ、C-erbB-2及bcl-2蛋白的表达情况,并作统计学分析。结果:96例乳腺癌组织标本中,ERβ、C-erbB-2及bcl-2蛋白阳性表达率分别为64.6%、36.5%和51.0%;ERβ蛋白的表达与组织学分级、C-erbB-2蛋白的表达呈负相关(P<0.05),与bcl-2蛋白的表达呈正相关,与腋淋巴结状态无关(P>0.05)。结论:ERβ蛋白表达可能是乳腺癌患者预后良好的指标。

Objectlve：To detect the expressions of ERβ, C -erbB -2 and bel -2 protein in breast cancer , and analyze the relationship between the expression of ERβ protein and tumor grade, the expression of C - erbB - 2 and bel - 2 protein. Methods： Immunohistochemistry S - P method was used to detect the expression of ERβ, C - erbB - 2 and bcl - 2 protein in 96 breast cancer samples. Rssult of detection were analyzed statistically. Results： The positive expression rates of ERβ, C - efbB -2 and bcl -2 protein were 64.6%, 36.5% and 51.0% respectively;The expression of ERβ protein had a negtive correlation with tumor grade and the expression of C - erbB - 2 protein（P 〈 0.05 ）, and had a positive correlation with the expression of bcl -2 protein, no correlation with axillary lymph node status（P 〉 0.05 ）. Conclusion： ERβ protein may be a useful marker which predicts good prognosis of breast cancer patients.