周剂量多西紫杉醇、奥沙利铂联合5-氟尿嘧啶/亚叶酸钙治疗晚期胃癌疗效观察

Weekly administration of docetaxel and oxaliplatin combined with 5-FU+LV for advanced gastric cancer

目的:观察周剂量多西紫杉醇、奥沙利铂联合5-氟尿嘧啶/亚叶酸钙治疗晚期胃癌的近期疗效,毒副作用及生活质量改善情况。方法:18例晚期胃癌患者以多西紫杉醇25mg/m2d1、d8、d15静脉滴注1小时,奥沙利铂65mg/m2d1、d8静脉滴注3小时,亚叶酸钙100mgd1～d5静脉滴注2小时,5-氟尿嘧啶500mg/m2d1-d5静脉滴注4小时。4周为1个周期,2周期为1个疗程。所有病人至少接受2周期以上。客观疗效(CR+PR)和毒副作用按WHO进行评价,生活质量按临床受益反应(CBR)进行评价。结果:18例均可评价疗效,完全缓解(CR)0例,部分缓解(PR)10例,总有效率55.6%,临床受益反应有效率72%,中位TTP5.6月。主要毒副反应为骨髓抑制,消化道反应和神经毒性,大部分为Ⅰ～Ⅱ级,可以耐受。结论:每周低剂量多西紫杉醇、奥沙利铂联合5-氟尿嘧啶/亚叶酸钙治疗晚期胃癌近期疗效好,毒副反应轻,耐受性好,病人生活质量明显改善。

Objective ：To observe the short term curative effect, toxicity and quality of life with weekly administration of docetaxel and oxaliplatin combined 5 - FU ＋ LV for advanced gastric cancer. Motheds ： Eighteen cases with advanced gastric cancer were observed. Docetaxel 25mg/m2 iv for 3h, dl, d8, d15. oxaliplatin 65mg/m2 iv for 3h. dl ,d8. LV 100mg iv for 2h d1 - d5. 5 - FU 500mg/m2 iv for 4h, d1- d5 and repeated every 28 days. To evaluate CR ＋ PR and toxicity refer to WHO standard, quality of life. Results： Total response rate was 55.6%. Clinical ben- efit effect rate was 72%. Median TIP was 5.6 months. Myelosuppresion, toxicity of digestive tract and nerve were Ⅰ - Ⅱgrade and tolerable. Conclusion ： Patients treated with the low - dose weekly administration of docetaxel and oxaliplatin combined 5 - FU ＋ LV for advanced gastric cancer had a superior response rate. Quality of life is improved obviously.