期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

明胶酶与恶性肿瘤 被引量：7

Gelatinase and malignant tumor
下载PDF
导出
摘要 肿瘤的发生、发展是多因素作用的结果,明胶酶在其中发挥着广泛作用,已成为目前研究的一个热点。本文将近些年对明胶酶的结构、作用底物、激活和抑制等方面的基本特性,以及它与恶性肿瘤的生长、血管发生、转移和治疗等方面的研究进展作一综述。 The development of tumor results from multiple factors. Gelatinase plays general roles in the process and it is a hot spot in research of malignant tumor. In this article, we review the achievement of last ten years＇researches on gelatinase, including it＇s basic characters, such as primary structure, substrates, activation and inhibition, and it roles in the growth and development of tumor, angiogenesis, metastasis and therapy.
作者 杨明 侯敢 黄迪南
机构地区 广东医学院生物化学与分子生物学研究所
出处 《现代肿瘤医学》 CAS 2008年第1期130-133,共4页 Journal of Modern Oncology
基金 广东省自然科学基金(编号:5011588) 广东省医学科研基金(编号:A2003544) 湛江市科技攻关项目(编号:ZK0404)
关键词 明胶酶 MMP-2 MMP-9 恶性肿瘤 gelatinase MMP - 2 MMP - 9 malignant tumor
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献36

  • 1Liotta LA. Tumor invasion and metastases - role of the extracellular matrix: Rhoads Memorial Award lecture[ J]. Cancer Res, 1986,46 (1):1 -7.
  • 2Stemlicht MD, Werb Z. How matrix metanoproteinases regulate cell behavior[J]. Annu Rev Cell Dev Biol, 2001, 17( 1 ) : 463 -516.
  • 3Somerville RP, Oblander SA, Apte SS. Matrix metalloproteinases: old dogs with new tricks [J]. Genome Biol, 2003, 4(6) :216.
  • 4McQuibban GA, Gong JH, Tam EM, et al. Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein -3[J]. Science, 2000, 289(5482):1202 - 1206.
  • 5Nelson AR, Fingleton B, Rothenberg ML, et al. Matrix metalloproteinases: biologic activity and clinical implications[J]. J Clin Oncol, 2000, 18(5) : 1135 - 1149.
  • 6Xu X, Wang Y, Lauer - Fields JL, et al. Contributions of the MMP- 2 collagen binding domain to gelatin cleavage. Substrate binding via the collagen binding domain is required for hydrolysis of gelatin but not short peptides [J]. Matrix Biol, 2004, 23(3) : 171 - 181.
  • 7Collier IE, Krasnov PA, Strongin AY, et al. Alanine scanning mutagenesis and functional analysis of the fibronectin - like collagen - binding domain from human 92 - kDa type Ⅳ collagenase [J]. J Biol Chem,1992, 267(10) : 6776 -6781.
  • 8Shipley JM, Doyle GA, Fliszar CJ ,et al. The structural basis for the elastolytic activity of the 92 - kDa and 72 - kDa gelatinases. Role of the fibronectin type Ⅱ - like repeats[ J]. J Biol Chem , 1996 ,271 (8) :4335-4341.
  • 9Hulboy DL, Rudoph LA, Matrisian LM. Matrix metalloproteinases as mediators of reproductive function[ J]. Mo Hum Reprod, 1997,3 (1) :27 -45 .
  • 10YU Q, Stamenkovic 1. Cell surface - localized matrix metallopro- teinase- 9 proteolytically activates TGF - β and promotes tumor invasion and angiogenesis [J]. Genes Dev, 2000, 14, (2) :163 - 176.

二级参考文献12

  • 1Ohtani M, Isozaki H, Fujii K,et al. Impact of the expression of cyclindependent kinase inhibitor p27^kipl and apoptosis in tumor cells on the over all survival of patients with nonearly stage gastric carcinoma. Cancer, 1999,85 (8): 1711-7.
  • 2Kleiner DE,Stetler-Stevenson WG. Matrix metalloproteinases and metastasis. Cancer Chemother Pharmacol, 1999,43(suppl):S42.
  • 3Kim DH, Lee HI, Nam ES, et al. Reduced expression of the cellcyclin inhibitor p27^kipl is associated with progression and lymph node metastasis of gastric carcinoma. Histopathology, 2000, 36(3):245-51.
  • 4Shin JY, Kim HS,Park J,et al. Mechanism for inactivation of the KIP family cyclin-dependent kinase inhibitor genes in gastric cancer cells. Cancer Res,2000,60(2):262-5.
  • 5Garbett EA, Reed MW, Brown NJ, et al. Proteolysis in human breast and colorectal cancer. Br J Cancer, 1999,81 (2) : 287-93.
  • 6Michael M, Babic B, Khokha R,et al. Expression and prognosis significance of metalloproteinase and their tissue inhibitors in patients with small-cell lung cancer. J Clin Oncol, 1999, 17 (6):1802-8.
  • 7Dipersio CM, Shao M, Di-Costanzo L, et al. Mouse keratinocytes immortalized with large T antigen acquire alpha 3 beta 1 integrin dependent secretion of MMP-9/gelatinase Br J Cell Sci, 2000,113(Pt16) :2909-21.
  • 8Ben Davidson , Iris Goldberg, Juri Kopolovic, et al. Expression of matrix metalloproteinase-9 in squamous cell carcinoma of the uterine cervix. Gynecol Oncol, 1999,72 (3):380-6.
  • 9Collins HM, Morris TM, Watson SA. Spectrum of matrix metalloproteinase expression in primary and metastatic colon cancer: relationship to the tissue inhibitors of metalloproteinase and membrane type-l-matrix metalloproteinase. Br J Cancer,2001,84(12) : 1664-70.
  • 10Horikawa T, Yoshizaki T, Sheen TS, et al. Association of Iatent membrane protein I and matrix metalloproteinase 9 with metastasis in masopharyngeal carcinoma. Cancer, 2000, 89 (4):715-23.

共引文献9

同被引文献49

引证文献7

二级引证文献30

现代肿瘤医学
2008年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部