FHIT基因与子宫颈癌的相关性研究

The study on the correlation between FHIT gene and cervical cancer

脆性组氨酸三联体(FHIT)基因是近年来发现的定位于人3号染色体短臂(3p14.2)上的候选抑癌基因。许多研究表明其表达改变与人类多种肿瘤关系密切。FHIT基因可能通过调控细胞周期,诱导细胞凋亡发挥抑制肿瘤的作用,其失活机制主要表现为启动子区域CPG岛甲基化、缺失及异常转录。本文重点综述FHIT基因的生物学特性及在宫颈癌发生发展中的作用。

Fragile histadine triad （FHIT） gene, a putative tumor suppressor gene, locates in chromosome region 3p14.2. Many studies revealed that the altered expression of FHIT is closely related to tumors. Its tumor suppression effect is obtained probably by inducing cell apoptosis, cell cycle retardation, the gene is inactivated involve methylation, deletions and aberrant transcription of CPG - island in its promoter zone. In this review, we summarized the role of FHIT in occurrence and development of cervical cancer .