胃肠道间质瘤71例预后影响因素分析

The analysis of the prognostic factors of the 71 gastrointestinal stroma tumors

目的探讨胃肠道间质瘤的诊断和治疗方式及影响术后复发的因素。方法对我院2001年1月～2007年6月收治并获随访的71例胃肠道间质瘤的临床资料进行回顾性分析。分别采用单因素和多因素两种方式对影响复发的因素进行分析。结果单因素分析显示,肿瘤大小、有无浸润、坏死和手术方式均对术后复发有影响(P<0.05);多因素分析显示,肿瘤大小、有无浸润和手术方式对术后复发有影响(P<0.05)。结论适当扩大切除范围,术后服用依马替尼可降低胃肠道间质瘤的术后复发率,改善病人预后。

Objective To further explore the diagnosis and treatment of gastrointestinal stromal tumor, and analyze the factors influencing the postoperative recurrence. Methods The clinical data of 71 patients with gastrointestinal stromal tumors admitted and followed up from January 2001 to June 2007 were analyzed retrospectively, and the potential factors influencing postoperative recurrence investigated by univariate and multivariate analysis respectively. Results Univariate analysis revealed that the tumor size, surrounding tissue invasion, necrosis and the resected procedures could significant- ly influence the postoperative recurrence （P ~ 0. 05）. Multivariate analysis showed tumor size, sur- rounding tissue invasion and the resected procedures could significantly influencing the postoperative recurrence（P〈0. 05）. Conclusion Extended resecting range advisably and Imatinib administration after operation could decrease the relapse rate and improve the prognosis.