原子吸收法建立舒筋活血中成药的无机元素的控制方法的探讨

Exploration of Quality Control of Inorganic Elements in Chinese Herbal Medicines for Stimulating Blood Circulation and Relaxing Muscles and Joints by Atomic Absorption Spectrophotometry

人们已认识到无机元素与中成药的疗效有密切相关。但是在研究舒筋活血中成药化学成分的质量控制时,无机成分常被忽视。文章用原子吸收光谱法,测定了中成药大活络丸和几种中药中15种无机元素Cu,Ca,Fe,K,Mg,Mo,Ni,Sr,V,Mn,Zn,Na,Cr,Cd和Hg的含量,探讨了无机元素与中药的药效关系,并通过大活络丸与几种中药所含无机元素含量的对照比较,得出大活络丸中Fe,Cu,Mn和Zn等与药效之间的关系。中成药大活络丸中所含一定量的Fe,Cu,Mn和Zn等微量元素与其祛风除湿,理气豁痰,舒筋活络等药效存在一定关联。对大活络丸的无机元素测定与分析可为今后其指纹图谱的建立提供数据和参考依据。

Researches have shown the close relationships between inorganic elements and curative efficiencies of various Chinese herbal medicines. Yet, in studies of chemical composition and quality control of Chinese herbal medicines for stimulating blood circulation and relaxing muscles and joints, inorganic substances are often overlooked. In order to improve and reestablish the standard of quality control of Chinese herbal medicines, the authors attempted a method that would incorporate the composition of inorganic elements as part of the quality control. In the present study, the authors used atomic absorption spectrophotometry to measure the contents of fifteen inorganic elements, namely, Cu, Ca, Fe, K, Mg, Mo, Ni, Sr, V, Mn, Zn, Na, Cr, Cd, and Hg, in several Chinese herbal medicines, including Da Huo Luo Wan. The authors then discussed the relationship between these inorganic elements and curative efficiencies of these Chinese herbal medicines. By comparing the levels of inorganic elements found in Da Huo Luo Wan with those found in other Chinese herbal medicines used in the study, it was revealed that trace elements, Fe, Cu, Mn, and Zn, contribute to the curative efficiency of Da Huo Luo Wan. The authors＇ results showed that the amounts of trace elements Fe, Cu, Mn and Zn found in Chinese herbal medicine Da Huo Luo Wan are related to the following curative effects of Da Huo Luo Wan ： relieving rheumatism, rectifying breathing and alleviating phlegm, stimulating blood circulation and relaxing muscles and joints. The measurement and analysis of inorganic elements in Da Huo Luo Wan will also provide evidences and references for the fingerprint establishment of Da Huo Luo Wan in the future.