蚓激酶对动脉粥样硬化及纤溶活性的干预研究

Efficacy of intervention with lumbrokinase on fibrinolytic activation for patients with carotid arteriosclerosis

目的探讨蚓激酶对动脉粥样硬化(Arteriosclerosis,AS)及纤溶活性的干预作用。方法将经彩超确诊的AS患者随机分为蚓激酶治疗组88例和对照组64例,观察治疗前后两组的血清纤维蛋白原(fibrinogen,Fbg)水平、组织型纤溶酶原激活剂(tissue-tipe plasminogen activator,tPA)、组织型纤溶酶原抑制剂(plasminogen activator inhibitor,PAI)活性、颈动脉内膜中层厚度(intima-media thickness,IMT)、斑块crouse评分变化情况。结果治疗组治疗后血清Fbg水平、tPA、PAI活性、颈动脉IMT、crouse评分改善明显优于对照组;不稳定性斑块组疗效好于稳定性斑块组。结论蚓激酶能延缓、逆转动脉粥样硬化并纠正纤溶紊乱。

Objective To explore the Efficacy of intervention with lumbrokinase on fibrinolytic activation for patients with carotid arteriosclerosis. Methods Patients with carotid arteriosclerosis diagnosed by color doppler ultrasound were randomly divided into lumbrokinace treatment group （n = 88）and control group （n = 64）. The change of plasma Fbg level ,TpA ,PAI activation ,IMT of carotid artery,crouse score in two groups were observed. Results The improved levels of plasma Fbg level, TpA,PAI activation,IMT of carotid artery,crouse score in treatment group were all better than those of the control group. The curative effect in vulnerable plaque group was better than stable plaque group. Conclusion Lumbrokinase can delay or reverse earotid arteriosclerosis and redress fibrinolytic activation disorder.