药品残留溶剂测定知识库及其应用

Fundamental research and application of the knowledge base for residual solvent determination in pharmaceuticals

目的:介绍药品残留溶剂测定知识库及其应用。方法:以加替沙星和西洛他唑残留溶剂的检测为例,探讨了药品残留溶剂测定知识库应用的基本过程。结果:应用知识库对加替沙星和西洛他唑中的残留溶剂进行了全面准确测定。结论:应用药品残留溶剂测定知识库能够快速、准确地鉴别出药品中未知的残留溶剂,是药品残留溶剂测定的有力工具。

Objective：To introduce the knowledge base for residual solvent determination in pharmaceuticals and its application. Methods： Gatifloxacin and ciloprost were chosen as samples, and the general process of using the knowledge base for residual solvent determination was approached. Results： The residual solvents in Gatifloxacin and ciloprost were determined roundly and accurately using the knowledge base. Conclusion： The residual solvents in pharmaceuticals can be identified rapidly and accurately using the knowledge base for residual solvent determination, making it a powerful tool for determining residual solvent in oharmaceuticals.