新乡地区甲状腺功能紊乱患者的年龄分布状况研究

Investigation on age distribution of patients with thyroid dysfunction in the population of Xinxiang area

目的研究新乡地区甲状腺功能紊乱患者的年龄分布状况，为预防和诊断甲状腺疾病提供依据。方法以2005年3月～2006年9月间在新乡市第一人民医院进行甲状腺功能检查的患者共3000例为研究对象，用磁分离酶联免疫法测定TSH、T3、T4、FT3、FT4，并对结果进行分析。结果在对方法学和试剂性能包括灵敏度、特异性、不精密度、不准确度进行评价后，建立了新乡地区正常人群的参考值。在此基础上对甲状腺激素代谢异常在不同年龄组的分布状况进行了研究，发现甲状腺激素代谢异常发病率女性高于男性，甲状腺功能亢进症（甲亢）主要分布在21～60岁之间，性别和年龄组间差异有统计学意义（X^2=35．936，P〈0．001）。甲状腺功能减退症（甲减）则在11～60岁之间呈均匀分布，虽然在31～40岁有一峰值，但各组间差异无统计学意义（X^2=4．542，P=0．604）。结论甲状腺激素代谢异常的发病率近年来有升高的趋势。与传统观念不同，甲亢患者有向老龄化发展的趋势，甲减则有向年轻化发展的趋势。

Objective To investigate age distribution of patients with thyroid dysfunction in the population of Xinxiang area, so as to provide basis for prevention and treatment of thyroid diseases. Methods ,3 000 patients undergoing thyroid function examination were enrolled in our investigation in our hospital from Mar 2005 to Sep 2006. TSH, T3 ,T4 , FT3 and FT4 were determinated by Biochem Immuno Systems SEROZYME type magnetism separated enzyme immunoassay, and the results were analyzed. Results The womenrs incidence of thyroid metabolic abnormity was higher than men＇s, Hyperthyroidism was mainly distributed between age 21 to 60. There were significant differences between sex groups and age groups （X^2=35. 936,P〈0. 001）. Hypothyroidism was distributed evenly between age 11 to 60. Although a peak value appeared between age 31 to 40, there was no significant difference between all groups （X^2= 4. 542, P= 0. 604）. Conclusion In the recent years, there is an elevatory trend for the incidence of thyroid metabolic abnormity. Different from traditional concept, there is an old age trend for hyperthyroidism, young trend for hypothyroidism.