神经生长因子改善实验性糖尿病大鼠的感觉神经功能

Improvement of sensory neuropathy by nerve growth factor in experimental diabetic rats

观察了链脲佐菌素糖尿病大鼠成模两个月后，投用神经生长因子（ＮＧＦ）对糖尿病神经病变的影响。结果显示，外源性注射ＮＧＦ１个月后，摇尾试验（一种鼠对热毒刺激的反应）热痛阈值明显恢复，坐骨神经的感觉神经传导速度有所改善。初步显示了ＮＧＦ对糖尿病感觉神经病变的治疗作用。

This study investigated the effects of administration of nerve growth factor (NGF) on diabetic neuropathy in diabetic rats two months after streptozotocin (STZ) induction.The results showed:after 1 month of injections improvements were seen in both tailfrick threshold (a measure of the rats response to a thermal noxious stimulus)and sciatic sensory nerve conduction velocity (SNCV).The findings suggested that the NGF might have some effect in the treatment for diabetic sensory neuropathy.