摘要
目的通过测定环丙沙星片剂的尿药浓度来研究其药动学参数，以指导临床合理用药。方法采用双波长法测定环丙沙星片剂的尿药浓度。结果环丙沙星在2～7μg·mL^-1浓度范围内线性良好，r=0．9999；平均回收率为99．9％，RSD=1．65％（n=5），在室温条件下稳定性良好；T1／2=3．96h。结论该法灵敏、准确、迅速；重复性好；尿样品处理方法简单。
OBJECTIVE To study pharmacokinetic and to guide the clinical reasonable use of the medicine by determinating Ciprofloxacin in urine. METHODS A double-wave length spectrophotomotry method was developed to determinate Ciprofloxacin in urine . RESULTS The linear range of Ciprofloxacin was 2 -7 μg · mL^- , the correlation coefficient was 0.9999. The average recovery rate was 99.9% ,the relative standard deviation was 1.65% under the indoor temperature,the stability was good; T1/2 = 3.96h . CONCLUSION The method is sensitive, accurate and quick , and its reproducibility is good . The urine sample handle method is simple.
出处
《海峡药学》
2007年第12期106-108,共3页
Strait Pharmaceutical Journal
关键词
环丙沙星
尿药浓度
双波长法
Ciprofloxacin
Concentration in urine
Double-wave length spectrophotomotry
