丙酸睾丸酮加强米非司酮终止50～68天早孕的研究

The Study of Termination of 50～68 Days Early Pregnancy with Mifepristone Strenghthened by Propionate Testosterone.

为探讨丙酸睾丸酮(简称丙睾)加强米非司酮终止50～68天早孕的作用,本文以68例丙睾、米非司酮、卡孕栓(PG05)药物流产为加丙睾组,30例米非司酮、卡孕栓药物流产为对照组,比较其临床效果及药效机制。临床两组间比较,加丙睾组完全流产率95.59%,对照组为76.67%,明显高于对照组(P<0.01),加丙睾组流产后出血天数为11.17天,对照组15.39天,少于对照组(P<0.05)。从流产物病理及组化改变上观察,对照组有绒毛水肿、滋养层细胞变性、坏死,周围有糖蛋白包绕,蜕膜轻度坏死。加丙睾组除有上述绒毛病变外,突出的改变是蜕膜细胞连同滋养层柱细胞大量坏死,残存的蜕膜细胞间的胶原纤维肿胀、变性,并有网状纤维破坏。结果显示序贯应用该三种药,对终止50～68天早孕确有高效。并皆作用于受体,系分子水平药物,有广阔发展前景。

To study the ettect of mnepristone strengthened by propionate testosterone on termination of 50～68 days early pregnancy,we compared 68 cases of combined testosterone with mifepristone and PG05 which are tak- en as an adding protionate testosterone group with 30 cases of only mifepristone and PG05 as a control group on medicine abortion and pharmacodynamics mecha- nism.Result:in clinical comparison between the two groups,the complete abortion rate is 95.59% in the adding propionate testosterone group,it is apparently higher than that in the control group which is 76.67 % (P<0.01).The bleeding time after abortion is 11.17 days in adding testosterone group and lower than 15.39 days in the control study group(P<0.05).In patholog- ical and histochemical we found out that villi showed edema,trophocyte degeneration,necrosis,binding edge of glucoprotein and decidua light necrosis in the control group,and in adding propionate testosterone group,in addition to above villi pathological state,its obvious change was that a large number of necrosis of decidua as well as cytotrophoblast column cell appeared.Colla- gen fiber among the residual decidua swelled,degener- ated.Reticulate fibers were destroyed.Conclusion: These results showed that it is very effective in termi- nation of 50～68 days early pregnancy in sequence of using 3 drugs.In this paper,we put forward that the three drugs which act on the receptor are of moleculer level medicine,and have great prospect.