摘要
1名44岁女性乳腺癌患者,于手术及化疗后服用他莫昔芬20mg/d作为辅助内分泌治疗。3个月后患者ALT、AST、γ-GT值升高,服用6个月时患者肝功能检查显示:ALT396U/L、AST278U/L、γ-GT211U/L。经保肝治疗后好转,后改用阿那曲唑、戈舍瑞林治疗,未再出现肝功能异常。
A 4.4-year-old women with breast cancer was treated with oral tamoxifen 20 mg/d as adjuvant endocrine therapy after breast operation and chemotherapy. Three months later, her levels of ALT, AST, and γ-GT increased. After 6 months of medication, her liver function examination showed the levels as follows： ALT 396 U/L, AST 278 U/L, and γ-GT 211 U/L. After liver-protective treatment, her hepatic function returned to normal limits. Then she was treated with anastrozole and goserelin instead of tamoxifen, and liver dysfunction did not recur.
出处
《药物不良反应杂志》
2007年第6期413-413,419,共2页
Adverse Drug Reactions Journal
关键词
他莫昔芬
肝损伤
tamoxifen
hepatic injury
