职业紧张对496名石化职工血浆腹脂素水平的影响

The Effect of Job Stress on Plasma Visfatin Level in 496 Petrochemical Workers

[目的]探讨职业紧张与血浆腹脂素水平及相关糖脂代谢指标的关系。[方法]采用工作内容问卷对4家石化企业496名职工进行调查,将工作控制<64分,且工作需求>36分的人群定为职业紧张组,其余为非职业紧张组。同时抽血,血浆腹脂素采用酶联免疫(EIA)方法检测,高密度脂蛋白(HDL)、总胆固醇(TC)、三酰甘油(TG)采用酶法测定,空腹血糖采用葡萄糖氧化酶法测定,空腹胰岛素采用化学发光法检测。胰岛素抵抗采用稳态模型评价法计算,分析职业紧张及其工作控制、工作需求以及社会支持三个因子与血浆腹脂素水平以及相关糖脂代谢指标的关系。[结果]职业紧张组血浆腹脂素水平显著高于非职业紧张组(F=3.94,P<0.05),且TG(F=14.07,P<0.001)、体质指数(BMI)(F=7.19,P<0.01)两组差异亦有统计学意义。对职业紧张3个因子分析结果显示,低工作控制组血浆腹脂素水平(t=2.2,P<0.05)和BMI(t=2.9,P<0.05)高于高工作控制组;高工作需求组BMI(t=2.4,P<0.05)和腰臀比(WHR)(t=2.6,P<0.05)高于低工作需求组。多元逐步回归分析显示低工作控制是血浆腹脂素水平升高的主要影响因素。[结论]职业紧张导致血浆腹脂素水平显著升高,低工作控制与血浆腹脂素水平呈负相关。

[ Objective ] To explore relationship between job stress and plasma visfatin. [ Methods ] 496 workers from 4 petrochemical industries were selected under investigation. Job content questionnaire was used in assessing job stress, which is defined as the score of job control 〈64 and of job demand 〉36. At the same time, their plasma visfatin and other relevant glycolipid metabolism indices in blood were tested. The relationships between plasma visfatin, HDL, TG, TC, BMI, WHR, insulin, insulin resistance, fasting glucose and job stress including its three factors （job demand, job control and social support ）were analyzed. [ Results ] Plasma visfatin level were significantly（ F=3.94, P 〈 0.05 ）higher in job stress group after age adjusted. TG（ F=14.07, P 〈 0.001 ）and BMI（ F=7.19, P 〈 0.01 ）showed the same inclination. For the three factors of job stress, plasma visfatin（ t=2.2, P 〈 0.05 ）and BMI （ t=2.9, P 〈 0.05 ）were significantly higher in low decision latitude group. WHR（ t=2.6, P 〈 0.05 ）and BMI（ t=2.4, P 〈 0.05 ）were significantly higher in high job demand group. Multiple stepwise regression analysis showed that low decision latitude was associated with plasma visfatin level. [ Conclusion ] Job stress and decision latitude are significantly associated with plasma visfatin level.