基质金属蛋白酶-9、磷酸化的促血管生成素受体-2在肌肉血管瘤中的表达及意义

The Expression and Significance of Matrix Metalloproteinase-9 and Phospho-Tie2 in Intramuscular Hemangioma

目的:检测肌肉血管瘤血管畸形组织中基质金属蛋白酶-9(MMP-9)及磷酸化的促血管生成素受体(Tie2)的表达,并探讨其意义。方法:收集肌肉血管瘤标本39例、正常颅面部皮下组织标本10例,采用ABC免疫组化染色检测MMP-9、磷酸化的Tie2的表达。结果:MMP-9、磷酸化的Tie2在肌肉血管瘤组织中的阳性表达远高于在正常皮下组织中的表达,差异具有统计学意义(P<0.01);其表达的强度在不同病程、瘤体大小、部位及浸润程度的病例中无明显差异(P>0.05)。结论:MMP-9、磷酸化的Tie2可能参与肌肉血管瘤发生、发展。

Objective：To investigate the expression and significance of matrix metalloproteinase-9（MMP-9）and Phospho-Tie2 in intramuscular hemangioma. Methods： Specimens of 39 intramuscular hemangiomas and 10 normal subcutaneous tissues in the faces were collected. The ABC immunohistochemical stain was used to investigate the expression of MMP-9 and Phospho-Tie2 in these samples. Results： The expression levels of MMP-9 and Phospho-Tie2 were significantly higher in intramuscular hemangiomas than in normal subcutaneous tissues（P〈0.01）. Their positive intensity had no significant difference statistically among the cases of different courses,locations,dimensions and infiltration degrees. Conclusion：MMP-9 and Phospho-Tie2 may be involved in the pathogenesis and development of intramuscular hemangioma.