米索前列醇终止中、晚期妊娠的临床研究

Clinical study of termination of 2nd and 3rd trimester pregnancy with intraveaginal misoprostol in 71 cases

本研究对71例妊娠12-36周的妇女（平均孕龄21．8周），自愿要求终止妊娠者，采用米索前列醇（misoprostol）800－1600μg分三次阴道给药（0小时、18小时、20小时或24小时）。观察给药至胎儿排出时间和用药后副作用。结果：米索前列醇单独阴道用药，不加任何辅助措施，62例（87.3％）在用药48小时内排出胎儿。若给予辅助治疗，催产素静滴（总量＜10单位）引产成功率为95．8％。平均引产时间22．8小时。平均出血约80ml，产后出血发生率1．4％。药物副作用主要表现为恶心呕吐、腹泻、发热，发生率分别为8．5％、25．4％、15．5％，停药后其症状自愈。提示：米索前列醇在中、晚期妊娠引产中，阴道给药配合辅助措施其引产成功率较高，副作用小，是一种非手术的、安全、高效、简便的药物引产方法。

In 71 women with 12-36 weeks pregnancy (an average of 21. 8 weeks), misoprostol of 800-1600 μg in 3 divided doses was given intravaginally to induce abortion. The patients were followed up carefully to observe whether there were any adverse effects. It was found that misoprostol without any supplementary agents could induce abortion in 62 cases (87.3%) and when a combination of misoprostol and intravenous dripping of pitocin less than 10 units could achieve a successful rate of 95. 8%. Bleeding after abortion occurred in 1. 41% of cses with an average amount of blood loss of 80 ml. The main side effects were those from the gastrointestinal tract such as nausea,vomiting, diarrhea and fever, which subsided spontaneously after the discontinuation of the drug.It is concluded that the termination of 2nd and 3rd trimester pregnancy with intravaginal misprostol can achieve a high successful rate with a little side effects and it is a nonoperative, safe, highly effective and simple method to terminate pregnancy with a drug.