黄精大枣等成分口服液缓解体力疲劳研究

Empirical Study on Alleviating Physical Fatigue by Oral Solution With Traditional Chinese Medicine in Rats

目的了解黄精大枣等成分口服液对小鼠的缓解体力疲劳功能。方法实验设5、10、15ml/(kg·bw)3个剂量组和1个阴性对照组。每天按20ml/(kg·bw)经口灌胃1次,连续灌胃30d。于末次给予受试物30min后,测定负重游泳时间、血清尿素、肝糖原含量及乳酸。根据实验结果评价该产品是否具有缓解体力疲劳功能。结果受试物对各剂量组动物的体重以及乳酸均无统计学意义;低、高剂量组动物的负重游泳时间与阴性对照组比较显著延长;中、高剂量组的血清尿素低于阴性对照组;3个剂量组的肝糖原含量也极显著升高。结论黄精大枣等成分口服液对小鼠具有缓解体力疲劳功能。

Objective To detect the effects of certain oral solution for alleviating physical fatigue in ICR rats. Methods The oral solution was garaged to 160 female ICR rats for 30 days, with doses of 5 ml, 10 ml, and 15 ml/kg · bw. 30 minutes after the last exposure, the burden swimming time, urea nitrogen in serum, level of glycogen and lactic acid were measured. According to the results of the test, whether the solution could alleviate physical fatigue or not could be evaluated. Results The body weight and level of lactic acid had no significant differences in all groups（P 〉0. 05）. The burdened swimming time prolonged significantly at doses of 5 ml, 15 ml/kg（all P 〈0. 05）, respectively. Urea nitrogen in serum（BUN） was decreased at doses of 10 ml, 15 ml/kg （all P 〈0. 01 ）. The level of glycogen were elevated compared with the control at three doses （all P 〈 0. 01 ）. Conclusion The oral solution with traditional Chinese medicine has the effect of alleviating physical fatigue.