氧氟沙星两种给药方案治疗下呼吸道感染的经济学分析

Pharmacoeconomic Analysis of 2 Therapeutic Schemes of Ofloxacin in Treating Lower Respiratory Tract Infections

目的对氧氟沙星两种不同给药方案治疗下呼吸道感染进行药物经济学评价。方法将105例下呼吸道细菌感染患者分为两组,A组53例采用氧氟沙星连续静脉滴注,B组52例采用氧氟沙星序贯治疗,观察疗效并采用药物经济学最小成本分析法、成本-效果分析法进行分析和评价。结果A组和B组的临床总有效率分别为84.91%和84.62%(P>0.05),B组的成本-效果比(5.01)不及A组(8.72),且在统计学上差异显著(P<0.05)。结论对下呼吸道细菌感染患者采用序贯治疗安全、有效,且经济合理。

Objective To evaluate the pharmacoeconomic outcome of 2 therapeutic schemes of ofloxacin in the treatment of lower respiratory tract infections. Methods 105 patients with lower respiratory tract infections were divided into group A and group B. Ofloxacin was given by continuous intravenous infusion in group A （53 cases）, while it was given by sequential therapy in group B （52 cases）. The therapeutic effects were observed,the cost-minimization analysis and cost-effectiveness analysis of pharmacoeconomics was used to compare 2 therapeutic schemes. Results The effective rates of group A and group B were 84.91% and 84.62% respectively, P 〉 0. 05. Costeffectiveness ratio of group B （5.01） was lower than that of group A （8.72）, P 〈0.05. Conclusion The sequential therapy is safe, effective, rational and economical.