β-环糊精为模板控制合成球状羟基磷灰石

Biomimetic Synthesis of Spherical Hydroxyapatite with β-cyclodextrin as Template

以Ca（NO3）2·4H2O和（NH4）3PO4·3H2O为反应物，β-环糊精（β-CD）为模板，成功地合成了直径为2．0—3．0μm的球状羟基磷灰石（HA）。用X射线粉末衍射分析（XRD）、傅里叶变换红外吸收光谱（FTIR）、扫描电子显微镜（SEM）和电导率测定等手段对所制得的样品进行了表征，结果表明β-CD的浓度很大程度地影响了HA的形貌。在1．0～1．5％／β-CD为模板的条件下可以合成直径为3．0μm左右的HA。β-环糊精与HA之间存在着相互作用促使了球状HA的生成，并讨论了这种作用的可能机理。

Spherical hydroxyapatite （HA） with diameter of 2.0-3.0μm was synthesized successfully. Using Ca （ NO3 ） 2 ·4H2O and （ NH4 ） 3PO4 ·3H2O as reagents and β-cyclodextrin （fl-CD） as template. The crystal phase, chemical composition, microstructure of the obtained HA were characterized by X-ray powder diffraction analysis （ XRD）, Fourier-transform infrared spectroscopy （FTIR） and scanning electron microscopy（SEM）. The results show that the concentration of β-CD significantly affects the morphologies of the HA. Spherical hydroxyapatite particle with diameter about 3.0μm can be synthesized using a certain concentration （1.0-1.5%） β-CD as template. Spherical apatite crystal forms because a high affinity between HA and β-CD.