系膜细胞外基质与糖尿病肾病

Extracellular Matrix and Diabetic Nephropathy

细胞外基质进行性积聚是导致糖尿病肾病发生、发展的重要病理基础。通过对细胞外基质成分及代谢相关途径包括糖代谢紊乱引发的葡萄糖转运蛋白表达、蛋白激酶C通路激活、糖激化终末产物及多元醇通路激活;细胞因子影响,以系统阐明糖尿病肾病发病过程中影响系膜细胞外基质的机制。

It was the important pathologic basis of diabetic nephropathy that extraeellular matrix gradually accumulation. This article was systematically clarified the pathogenesis mechanism of diabetic nephropathy which affected composition and metabolism of the extraeellular matrix, including the expression of glucose transporter protein, pathway activation of PKC, AGEs, PP caused by glucose metabolic disorder and the impact of eytokines.