1[1]Brownlee M.Biochemistry and molecular cell biology of diabetic complications[J].Nature,2001,414 (6865):813-820.
2[2]Du XL,Matsumura T,Edelstein D,et al.Inhibition of GAPDH activity by poly (ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells[J].J Clin Invest,2003,112 (7):1049-1057.
3[3]Guangda X,Yuhua W.Apolipoprotein E4 allele and endotheliamdependent arterial dilation in type 2 diabetes mellitus without angiopathy[J].Diabetologia,2003,6 (4):514-519.
4[4]AndreasFesta,RalphD',Agostino,et al.Inflammation and miroalburninur-ia in nondiabetic and type 2 diabetic subjects:The insulin Resistance Atherosclerosis Study[J].Kidney International,2000,58:1703.
1Hurks R,Eisinger MJ,Goovaerts I,et a1.Early endothelial dys-function in young type I diabetics[J].Eur J Vasc Endovasc Surg,2009,37:611-615.
2Hansson GK.Inflammation,atherosclerosis and coronary artery disease[J].New Engl J Med,2005,352(16):1685-1695.
3Xian-pei H,Ke-ji C,Zhen-feng H,et al.Glucose endothelial cytotoxicity and protection by Dan Gua-Fang,a chinese herb prescription in huVEC in hyperglycemia medium[J].J Diabetes Complications,2008,23(5):297-303.
4Goto Y,Kakizaki M.The spontaneous-diabetes rat:a model of noninsulin dependent diabetes mellitus[J].Proc Japan Acad,1981,57:381-384.
5Portha B.Programmed disorders of beta-cell development and function as one cause for type2diabetes The GK rat paradigm[J].Diabetes Metab Res Rev,2005,21(6):495-504.
6Gill-Randall RI,Adams D,Ollerton RL,et a1.Is human type2 diabetes masternally inherited Insights from an animal model[J].Diabetic Medicine,2004,21:759-762.
7Minokoshi Y,Alquier T,Furukawa N,et al.AMP-kinase regu-lates food intake by responding to hormonal and nutrient signals in the hypothalamus[J].Nature,28:569-574.
8Andersson U,Filipsson K,Abbott CR,et a1.AMP-activated protein kinase plays a role in the control of food intake[J].J Bi-ol Chem,2004,279:12005-12008.
9Chau-Van C,Gamba M,Salvi R,et al.metformin inhibits a-denosine5’-monophosphate-activated kinase activation and prevents increases in neuropeptide Y expression in cultured hy-pothalamic neurons[J].Endocrinology,2007,148:507-511.
