摘要
目的:研究荜澄茄、干姜、石菖蒲挥发油对乌头碱经皮渗透的影响。方法:采用改良Franz扩散池法,以HPLC法测定模型药物乌头碱的累积渗透量,考察不同浓度的荜澄茄、干姜、石菖蒲挥发油对乌头碱的促渗效果。结果:7%浓度的荜澄茄、干姜、石菖蒲挥发油与3%氮酮的渗透系数(×10-3cm/h)分别为:10.79、5.82、5.40、3.91,与无促渗剂的对照组比较,差异均具有显著性意义,促渗倍数分别为3.87、2.09、1.94、1.40倍,可见7%的3种挥发油促渗倍数均大于3%氮酮。结论:7%的荜澄茄、干姜、石菖蒲挥发油均能明显促进乌头碱的经皮渗透。
Objective: To study the effect of volatile oil of Fructus Litseae(FL) , Rhizoma Zingiberis(RZ) and Rhizoma Acori Talarinowii (RAT) on percutaneous penetration of aconitine through mouse skin in vitro . Methods : By using improved Franz diffusion cells , the effects of these 3 volatile oils on the percutaneous penetration of aconitine were observed and compared with azone , and the cumulative amount of aconitine was determined by HPLC. Results : The penetration coefficient of aconitine with 7 % (v/v) volatile oil of FL, RZ and RAT and 3 % azone were 10.79,5.82,5.40,3.91, respectively; Compared with the group without penetration enhancers, the differences were significannt; and the enhancement ratios were 3.87,2.09, 1.94 and 1.40, respectively, which showed the enhancement ratios of 7 % of the 3 volatile oils were higher than that of 3 % azone . Conclusion : The 7 % volatile oils of FL, RZ and RAT enhance the permeation of aconitine effectively.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2008年第1期40-42,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金项目(No.30560187)
关键词
促渗剂
乌头碱
荜澄茄油
干姜油
石菖蒲油
Penetration enhancers
Aconitine
Volatile oil of Fructus Litseae
Volatile oil of Rhizoma Zingiberis
Volatile oil of Rhizoma Acori Tatarinowii